Questions & Answers
Shingles - The Disease
Back to Parent Q&A Category Back to All Shingles Q&A Back to All Q&A Back to Shingles

Overview

Questions
Answers
  1. What causes shingles?
    Shingles, or herpes zoster, is caused by the varicella-zoster virus (VZV), which, during first infection, produces chickenpox (varicella). After initial infection, the virus remains hidden (latent) in the nerve endings of the body until it reactivates, producing zoster or "shingles". Shingles is most common after the age of 50 and the risk of developing the disease increases with advancing age. Shingles causes numbness, itching or severe pain followed by clusters of blister-like skin sores along the distribution of nerve roots of one side of the face or body. The pain can persist for weeks, months or years after the rash heals and is then known as post-herpetic neuralgia (PHN).

  2. How do you know if you have shingles?
    Often the first symptoms of shingles may be numbness, tingling, itching, or pain in one particular location on one side of the face or body. In the pre-eruption stage, diagnosis may be difficult, and the pain can be so severe that it may be mistaken for pleurisy, kidney stones, gallstones, appendicitis, or even a heart attack, depending on the location of the affected nerve. The virus infects the skin cells and creates a painful, red rash that resembles chickenpox. Doctors can distinguish shingles from chickenpox by the way the spots are distributed. The rash usually appears in a well-defined band on one side of the body, typically the torso; or on one side of the face, around the nose and eyes. The rash usually begins as clusters of small bumps that soon develop into fluid-filled blisters (vesicles). The blisters fill with pus, break open, and form crusty scabs. In about four or five weeks, the disease will have run its course, and the skin will begin healing. Even after the blisters have healed the site may remain painful to the slightest touch or breeze. It is usually a very painful rash, and typically people can't bear clothes touching the affected area.

  3. How serious is shingles, especially to the Armed Forces?

    Most healthy individuals make an uneventful recovery. Although it's difficult to resist scratching the itchy rash, it is best to keep hands off, to prevent a bacterial infection that may require antibiotic treatment. After an infection, the skin may be left with significant scarring, which may be serious enough to require plastic surgery.

    Another complication, Ramsay Hunt syndrome, occurs when the varicella-zoster virus spreads to the facial nerve, causing facial paralysis, intense ear pain and vesicles in the auditory canal and outer ear structures (auricle). The rash might appear on the outer ear, inside the ear canal, on the soft palate (part of the roof of the mouth), or around the mouth and on the face, neck, and scalp. The hearing loss, vertigo, and facial paralysis that may result are usually, but not always, temporary.

    Occasionally, the rash will appear as a single spot or cluster of spots on the tip of the nose. This symptom is called Hutchinson's sign. The ophthalmic nerve is often involved and the eye may become affected, causing temporary or permanent blindness. If the eye is affected (ophthalmic herpes) or looks like it may become affected, an eye specialist (ophthalmologist) should be consulted.

    Shingles is a serious threat to immunosuppressed individuals - for example, those with HIV infection, individuals who are receiving cancer treatments and those that have received organ transplants. In those whose immune systems are extremely weakened, the varicella zoster virus can also spread to the internal organs and affect the lungs, central nervous system and the brain, possibly leading to death.



  4. Is there a treatment for shingles?

    Although viral diseases can't be cured, doctors can prescribe oral antiviral medications, such as Zovirax® (acyclovir), Famvir® (famciclovir) and Valtrex® (valacyclovir), that help control the infection by hindering reproduction of the virus in the nerve cells. Antiviral drugs may also help prevent the painful after-effects of shingles known as postherpetic neuralgia or PHN. Other treatments for PHN include steroids, antidepressants, anticonvulsants, and topical agents.

    To relieve pain, the doctor may recommend over-the-counter analgesics (pain-relieving drugs), such as ibuprofen and naproxen, or prescription drugs, such as indomethacin, all members of a class of medications known as nonsteroidal anti-inflammatory drugs. Acetaminophen is also commonly used to relieve the pain. If pain is severe, doctors may add stronger analgesics, such as codeine or oxycodone. If any of the blisters become infected it may take longer for the site to heal. Infections may be treated with antibiotics, in the form of a cream, or taken by mouth.

    In the case of ophthalmic herpes zoster, treatment is likely to involve specific anti-viral eye drops, and possibly treatment by mouth as well. In the event of long-lasting pain (PHN), a pain specialist could be consulted.



  5. How are shingles and chickenpox related?
    Both chickenpox and shingles are caused by the same virus (varicella). After a person has had chickenpox, the virus stays in the body permanently. About 10%-20% of all people who have been infected with chickenpox later develop the disease known as herpes zoster, or shingles. Symptoms of shingles are pain, itching, blisters, and loss of feeling along a nerve. Most cases occur in people older than 50, and the risk of developing shingles increases with age.

  6. What should I do if I get shingles?
    Contact your health care provider as soon as possible to discuss treatment with antiviral medications. These medications are most effective if given as soon as possible after rash onset.