No. The symptoms of the disease start with body ache and sometimes vomiting with a high fever over 101o. Over the next few days, pus-filled blisters develop over large portions of the body.
The vaccine side effects are usually limited to itching, fever, body ache, swollen lymph nodes, sore arm, mild rash as well as a rash at the injection site. People given a smallpox vaccination need to know the expected response at the vaccination site.