The IHB Clinical Investigations Division conducts clinical studies dedicated to understanding diversity in immune responses to vaccines
when delivered to large populations, and the impact of this diversity on efficacy and safety. These studies hold enormous potential for improving
the quality of care and reducing the rate and severity of adverse events following immunization. Through these projects, we also hope to improve
the quality of life for those who are adversely impacted by immunizations, reduce healthcare costs and disease rates through increased vaccination rates,
and increase the acceptability of vaccine programs.
The Clinical Investigations Office collaborates with other military, government, and academic research organizations to develop and implement
vaccine clinical research projects considered essential to national and military safety and defense. We are currently enrolling subjects in several
studies at Walter Reed National Military Medical Center, Bethesda, MD and Womack Army Medical Center, Fort Bragg, NC.
Currently Seeking Volunteers
Molecular and Immunologic Analysis of Anthrax Vaccine Immune Responses in the Context of Adverse Events
This study, conducted in collaboration with the Oklahoma Medical Research Foundation, aims to improve the understanding
of differences in immune responses to anthrax vaccine, evaluating both the quantity and quality of antibodies produced.
Genetic testing will also be performed to determine if there are specific markers for (1) those who produce higher antibody
responses to the vaccine, or (2) individuals who experience specific symptoms following receipt of the vaccine.
We are currently enrolling individuals who experienced no adverse reactions to multiple anthrax vaccines and individuals who experienced selected adverse events (e.g., new, lingering headaches,
joint aches, muscle aches, and/or fatigue; large, local reactions) following receipt of the vaccine.
All study participants must be eligible for care through the military healthcare system.
Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD
Womack Army Medical Center (WAMC), Fort Bragg, NC
Questionnaires and blood draw
Duration of participation:
One visit to WRNMMC or WAMC; annual follow-up e-mail questionnaires
Dr. Limone Collins, MD
For further information, please contact us at IHBclinicalstudies@mail.mil