Questions & Answers
Adenovirus - Adenovirus Types 4 and 7 Vaccine
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  1. Is there an FDA licensed vaccine for adenovirus?
    Yes. The FDA licensed the adenovirus vaccine on 16 March 2011 for types 4 and 7 for military populations, 17 to 50 years of age.

  2. Who should get adenovirus vaccine?
    The current DoD policy requires the Services to administer adenovirus vaccine to all enlisted military recruits in accordance with Immunizations and Chemoprophylaxis for the Prevention of Infectious Diseases (Joint Publication).

  3. What side effects have been reported with the adenovirus vaccine?
    A vaccine, like any medicine, could cause a serious reaction. But the risk of a vaccine causing serious harm, or death, is extremely small. Several mild problems were reported within 2 weeks of getting the vaccine: headache, upper respiratory tract infection (about 1 person in 3), stuffy nose, sore throat, joint pain (about 1 person in 6), abdominal pain, cough, nausea (about 1 person in 7), diarrhea (about 1 person in 10), and fever (about 1 person in 100). More serious problems have been reported by about 1 person in 100, within 6 months of vaccination. These problems included: blood in the urine or stool, pneumonia, and inflammation of the stomach or intestines. It is not clear whether these common or serious adverse events were caused by the vaccine or occurred after vaccination by chance.

  4. How effective is the adenovirus vaccine?

    Large-scale studies of the new vaccine in U.S. military recruits showed high efficacy rates in preventing wild type 4 adenovirus-associated febrile acute respiratory disease and inducing neutralizing antibody to type 7 adenovirus.

  5. What are the components of the adenovirus vaccine?

    The adenovirus vaccine contains viable, selected strains of human adenovirus Type 4 and human adenovirus Type 7 prepared in human-diploid fibroblast cell cultures (strain WI-38). The virus strains have not been attenuated. The cells are grown and the virus growth maintained in Dulbecco's Modified Eagle's Medium, fetal bovine serum, and sodium bicarbonate.